This map was taken from here: Where life expectancy is falling (in one map). Key quote:
The areas are by and large rural and lower income. They also tend to be areas with fewer doctors, likely meaning less access to the health care resources available elsewhere in the country.
I would be interested to know obesity rates and smoking rates in these areas. Also it is noteworthy that it is concentrated in the South of the U.S. I don’t know if there is a cultural element coming in there (and it would likely be hard to measure, especially compared to concrete things such as obesity, exercise rates, smoking, etc.).
Regardless, it’s not good.
P.S. Obesity rates are here and they overlap to a great degree.