If you find that you are feeling overwhelmed with work or the people at work, then you might find either one of these articles from the zenhabits blog to be useful: 13 small things to simplify your workday and 10 Ways to Deal With the Non-Simplifying Others in Your Life. If you read them now and then go on with your weekend activities, you may find that you have a plan to deal with these difficulties, come Monday. At the very least, knowing you have options can help you have a more relaxing weekend.
Good luck! Bon courage!